Clinical Study Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson’s Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study
نویسندگان
چکیده
1 Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain 2 Hospital Santa Maria de Lleida, 25007 Lleida, Spain 3 Hospital de Mataró, 08302 Barcelona, Spain 4 Hospital del Mar, 08003 Barcelona, Spain 5 Hospital de Granollers, 08401 Barcelona, Spain 6 Hospital Son Espases, 07120 Barcelona, Spain 7 Corporació Sanitària Parc Tauĺı, 08208 Barcelona, Spain 8 Hospital de Martorell, 08760 Martorell, Spain 9 Hospital General de Catalunya, 08915 Barcelona, Spain 10Hospital de Figueres, 17600 Girona, Spain 11Hospital Germans Trias i Pujol, 07014 Barcelona, Spain
منابع مشابه
Transdermal Rotigotine Improves Sleep Fragmentation in Parkinson's Disease: Results of the Multicenter, Prospective SLEEP-FRAM Study
Sleep disturbances occur frequently in patients with Parkinson's disease (PD). The aim of this study was to investigate the effects of rotigotine on sleep fluctuations in a sample of PD patients with self-reported complaints of nocturnal awakenings. This prospective, open-label, observational, and multicenter study enrolled consecutive outpatients with PD and administered rotigotine (mean dose ...
متن کاملNight-time use of rotigotine in advanced Parkinson's disease.
Transdermal rotigotine was used in six patients with advanced Parkinson's disease and sleep disorders (UPDRS part II item 12 score ≥ 2) receiving oral levodopa and diurnal apomorphine infusions. Transdermal rotigotine (2-4 mg/24h) was used at night for four months. Sleep disorders improved, the total Parkinson's Disease Sleep Scale score falling by an average of 45%; significant improvements em...
متن کاملRotigotine transdermal system as add-on to oral dopamine agonist in advanced Parkinson’s disease: an open-label study
BACKGROUND Achieving optimal symptom control with minimal side effects is a major goal in clinical practice. Dual-agent dopamine receptor agonist (DA) therapy in Parkinson's disease (PD) may represent a promising approach to treatment, as the combination of different pharmacokinetic/pharmacological profiles may result in a lesser need for high dosages and, accordingly, may be well tolerated. Th...
متن کاملRotigotine transdermal system and evaluation of pain in patients with Parkinson’s disease: a post hoc analysis of the RECOVER study
BACKGROUND Pain is a troublesome non-motor symptom of Parkinson's disease (PD). The RECOVER (Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; Clintrials.gov: NCT00474058) study demonstrated significant improvements in early-morning motor function (UPDRS III) and sleep disturbances (PDSS-2) with rotigotine transdermal system. Improvements were also reported on a Likert pain...
متن کاملSafety and Efficacy of a Transdermal Rotigotine for the Treatment of Fatigue and Quality of Life in Patients with Parkinson’s Disease
Aim: To evaluate safety and efficacy of a transdermal rotigotine for the treatment of fatigue and quality of life (QOL) in patients with Parkinson’s disease (PD). This was a multi-sites open-label study of 58 PD patients (male 26, female 32) who met a Japanese PD diagnosis criterion. They received a transdermal rotigotine 4.5 mg/day for 8 weeks. We added a rotigotine on the previous anti-Parkin...
متن کامل